The UNC/NC State scientists tested this therapeutic gel-mediated approach against two cancers – B16F10 melanoma and 4T1 breast cancer, the latter being low immunogenic. The method was effective at making the tumor microenvironments susceptible to treatment. And when the payload was released, tumors decreased significantly. The researchers then conducted experiments to have the hydrogel scaffold form at the surgical site after removal of primary tumors. They witnessed a remarkable inhibition of cancer recurrence.